Cornea and Ocular Surface Disease

[Keratoprosthesis in cornea and ocular surface diseases].

In 1771, Guillaume Pellier de Quengsy,1 an ophthalmologist, proposed for the first time the possibility of substituting opacifie corneal tissue by “an artificial cornea”. The proposal was for transparent glass plates to substitute the opaque cornea in order to enhance the transparency of optic media. Improvements in topical and systemic immunosuppression and limbus transplant techniques for tre...

Trafficking of Immune Cells in the Cornea and Ocular Surface

The role of immuno-inflammatory responses in the cornea and ocular surface has continuously been evolving over the past decades and has been becoming the center stage for therapeutic approaches for many diseases. In fact, the relevance of inflammation as a significant component in the pathophysiology of most acute and chronic forms of corneal and ocular surface diseases (e.g., microbial keratit...

An Update on Ocular Surface Epithelial Stem Cells: Cornea and Conjunctiva

The human ocular surface (front surface of the eye) is formed by two different types of epithelia: the corneal epithelium centrally and the conjunctival epithelium that surrounds this. These two epithelia are maintained by different stem cell populations (limbal stem cells for the corneal epithelium and the conjunctival epithelial stem cells). In this review, we provide an update on our underst...

Characteristics of the cornea and ocular surface in patients with congenital aniridia Introduction

Interactions between ocular surface fluid and cornea related to contact lenses.

PURPOSE To improve the quantification of damage to the ocular surface, metabolite levels, electrolyte concentrations, and enzyme activities were assayed in corneal epithelium, stroma and tears. METHODS In rabbits, rinsing or contact lenses were used to induce microtrauma. For more severe trauma, experimental injuries were induced with 1 N NaOH. Human accidents included epithelial lesions and ...